Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients

Joe Sasadeusz; Andrew Grigg; Peter D Hughes; Seng Lee Lim; Michaela Lucas; Geoff McColl; Sue Anne McLachlan; Marion G Peters; Nicholas Shackel; Monica Slavin; Vijaya Sundararajan; Alexander Thompson; Joseph Doyle; James Rickard; Peter De Cruz; Robert G Gish; Kumar Visvanathan

doi:10.1016/j.cld.2019.04.010

Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients

Clin Liver Dis. 2019 Aug;23(3):493-509. doi: 10.1016/j.cld.2019.04.010. Epub 2019 Jun 6.

Authors

Joe Sasadeusz¹, Andrew Grigg², Peter D Hughes³, Seng Lee Lim⁴, Michaela Lucas⁵, Geoff McColl⁶, Sue Anne McLachlan⁷, Marion G Peters⁸, Nicholas Shackel⁹, Monica Slavin¹⁰, Vijaya Sundararajan¹¹, Alexander Thompson¹², Joseph Doyle¹³, James Rickard², Peter De Cruz¹⁴, Robert G Gish¹⁵, Kumar Visvanathan¹²

Affiliations

¹ Peter Doherty Institute for Infection and Immunity, Elizabeth Street, Melbourne, Victoria 3000, Australia; University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia. Electronic address: j.sasadeusz@mh.org.au.
² Olivia Newton John Cancer Research Institute, Austin Hospital, 145 Studley Road, Heidelberg, Victoria 3084, Australia.
³ University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia.
⁴ National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119077, Singapore.
⁵ University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
⁶ University of Queensland Oral Health Centre, 288 Herston Road, Queensland 4006, Australia.
⁷ St Vincent's Hospital, 41 Victoria Street, Fitzroy, Victoria 3065, Australia.
⁸ University of California, San Francisco, S357 Parnassus Avenue, San Francisco, CA 94143, USA.
⁹ Ingham Institute, 1 Campbell Street, Liverpool, Sydney, New South Wales 2170, Australia.
¹⁰ Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Victorian Comprehensive Cancer Centre, 305 Grattan Street, Melbourne, Victoria 3000, Australia.
¹¹ University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; St Vincent's Hospital, 41 Victoria Street, Fitzroy, Victoria 3065, Australia; Department of Public Health, La Trobe University, Plenty Road, Bundoora, Victoria 3086, Australia.
¹² University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia; St Vincent's Hospital, 41 Victoria Street, Fitzroy, Victoria 3065, Australia.
¹³ The Alfred and Monash University, 85 Commercial Road, Melbourne, Victoria 3004, Australia; Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.
¹⁴ University of Melbourne, Grattan Street, Parkville, Victoria 3010, Australia.
¹⁵ Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA.

PMID: 31266623
DOI: 10.1016/j.cld.2019.04.010

Abstract

Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti-hepatitis B core antibody-positive only or both anti-hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.

Keywords: Hepatitis B; Prophylaxis; Reactivation; Transmission; Transplantation.

Publication types

Review

MeSH terms

Antiviral Agents / therapeutic use
Disease Transmission, Infectious
Female
Graft Survival
Graft vs Host Disease / immunology*
Graft vs Host Disease / physiopathology
Hepatitis B / drug therapy
Hepatitis B / prevention & control*
Hepatitis B virus / drug effects*
Hepatitis B virus / immunology
Humans
Liver Transplantation / adverse effects*
Liver Transplantation / methods
Male
Mass Screening
Prognosis
Survival Analysis
Transplant Recipients
Treatment Outcome
Virus Activation / drug effects
Virus Activation / immunology*

Substances

Antiviral Agents